Línea fundacional de la Sección Bioquímica, liderada por el Dr. Ricardo Ehrlich. El objetivo de esta línea fue el aislamiento y caracterización de genes vinculados al desarrollo y morfogénesis del cestodo Echinococcus granulosus, agente causante de la hidatidosis.
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Responsable: ehrlichricardo@gmail.com
Publicaciones
Ehrlich, R., Castillo, E., Chalar, C., Esteves, A., Fielitz, W., Garat, B., Marín, M., Martínez, C., Oliver, G., Pereira, Z., Picón, M. & Señorale, M..: "Echinococcus granulosus: Towards the understanding of parasitic adaptation". Basic Resarch in Helminthiases. Edited by R. Ehrlich, A. Nieto and L. Yarzabal. Ediciones Logos, Montevideo, Uruguay. pp 75-85 (1991).
Oliver, G., Vispo, M., Mailhos, A., Martínez, C., Fielitz, W., Sosa, B. & Ehrlich, R.: "Homeoboxes in Flatworms". Gene, 121: 337-342. (1992).
Ehrlich, R., Chalar, C., Dallagiovanna, B., Esteves, A., Gorfinkiel, N., Martínez, C. & Oliver, G.: “Echinococcus granulosus development: Transcription factors and differentiation markers”, in: “Molecular Biology and Immunology of the Adaptation and Differentiation of Parasites”. Ehrlich et al. eds. Ed. Logos. Montevideo, Uruguay. pp. 217-231. (1994).
Garat, B., Esperón, P., Martínez, C., Robello, C. & Ehrlich, R.: “Presence of a conserved domain of GATA-transcription factors in Echinococcus granulosus”. Journal of Helminthology, 71: 335-338 (1997).
Martínez, C., Chalar, C., González, J. and Ehrlich, R.: “The homeobox-containing gene EgHbx3 is expressed in the stalks of protoscoleces of Echinococcus granulosus”. International Journal for Parasitolgy, 27(11): 1379-1381 (1997).
Fu, Y., Martínez, C., Chalar, C., Craig, P.S., Ehrlich, R., Petavy, F. and Bosquet, G.: “A new potent antigen from Echinococcus granulosus associated with muscles and tegument”. Molecular and Biochemical Parasitology, 102(1): 43-52 (1999).
Chalar, C., Martínez, C., Agorio, A., Salinas, G., Soto, J. and Ehrlich, R.: “Molecular Cloning and Characterization of a Thioredoxin gene from Echinococcus granulosus”. Biochemical and Biophysical Research Communications, 262(1): 302-307 (1999).
Fernández, V., Chalar, C., Martínez, C., Musto, H., Zaha, A. and Fernández, C.: “Echinococcus granulosus: Molecular Cloning and Phylogenetic Analysis of a Transcriptionally Inducible Gluthathione S-Transferase”, Experimental Parasitology, 96: 190-194 (2000).
Martínez, C, Paredes, R, Stock, RP, Saralegui, A, Andreu, M, Cabezón, C, Ehrlich, R and Galanti, N: “Cellular Organization and Appearance of Differentiated Structures in Developing Stages of the Parasitic Platyhelminth Echinococcus granulosus”. Journal of Cellular Biochemistry, 94(2): 327-335 (2005).
Travençolo, BAN, Martínez, C, Beletti, ME, Sotelo Silveira, JR, Ehrlich, R and da F. Costa, L: “A distance-based approach to quantify the interplay between genetic activity and anatomy”, Journal of Anatomy, 210(2):221-31 (2007).
Chalar C. & Martínez Debat, C.: “NK homeobox-containing genes in platyhelminths”, en “Research in Helminths”. Adriana Esteves, Ed. Kerala, India: Transworld Research Network. ISBN: 978-81-7895-515-5. pp. 41-55 (2011).
Alvite G., Chalar C., Martínez Debat C. & Esteves A.: “Insights into Key Molecules of Echinococcus granulosus”. J Vet Med Res. ISSN: 2378-931X. 3(5): 1065. https://www.jscimedcentral.com/VeterinaryMedicine/veterinarymedicine-3-1065.pdf. (2016).
Chalar C., Martínez Debat C., Brauer M., Ehrlich R. and Marín M.: “eghbx2, a homeobox-gene involved in the maturation of calcified structures in Echinococcus granulosus”. Gene Reports 3:39-46. doi: 10.1016/j.genrep.2016.02.001. (2016).