Las tecnologías ómicas (genómica, transcriptómica y proteómica) son cada vez más utilizadas en diferentes líneas de investigación. En esta línea se busca apoyar a investigadores en el análisis de estos datos masivos, como el ensamblado de genomas, análisis de transcriptomas y expresión diferencial, análisis de datos proteómicos y estudios filogenéticos básicos.
Integrantes
Responsable. acostabile@fcien.edu.uy
Publicaciones
Margenat, M; Betancour, G; Irving, V; Costábile, A; García-Cedrés, T; Portela, MM; Carrión, F; Herrera, FE; Villarino, A. Characteristics of Mycobacterium tuberculosis PtpA interaction and activity on the alpha subunit of human mitochondrial trifunctional protein, a key enzyme of lipid metabolism. Front Cell Infect Microbiol. 2023 Jun 22 (13) 1095060. doi: 10.3389/fcimb.2023.1095060.
Costábile, A; Castellano, M; Aversa-Marnai, M; Quartiani, I; Conijeski, D; Perretta, A; Villarino, A; Silva-Álvarez, V; Ferreira, AM. A different transcriptional landscape sheds light on Russian sturgeon (Acipenser gueldenstaedtii) mechanisms to cope with bacterial infection and chronic heat stress. Fish and Shellfish Immunology. 2022, 128: 505–522. doi: https://doi.org/10.1016/j.fsi.2022.08.022.
Dourron, J; de Ovalle, S; González-Pombo, P; Villarino, A; Ramón, A*; & Costábile, A*. Genome sequencing and oenologically relevant traits of the Uruguayan native yeast Issatchenkia terricola. OENO One. 2022, 56(3): 103–119. doi: https://doi.org/10.20870/oeno-one.2022.56.3.5581. *Autor de correspondencia compartido.
Chalar, C; Clivio, G; Montagne, J; Costábile, A; Lima, A; Papa, N.G; Berois, N; Arezo, M.J. Embryonic developmental arrest in the annual killifish Austrolebias charrua: A proteomic approach to diapause III. PLoS ONE. 2021, 16(6): e0251820. doi: 10.1371/journal.pone.0251820
Choi, YJ; Fontenla, S; Fischer, PU; Le, TH; Costábile, A; Blair, D; Brindley, PJ, Tort, JF, Cabada, MM, Mitreva, M. Adaptive radiation of the flukes of the family Fasciolidae inferred from genome-wide comparisons of key species. Molecular Biology and Evolution. 2019; Sep 10. pii: msz204. doi: 10.1093/molbev/msz204.
Marizcurrena, JJ; Herrera, LM; Costábile, A; Morales, D; Villadóniga, C; Eizmendi, A; Davyt, D; Castro-Sowinski, S: Validating biochemical features at the genome level in the Antarctic bacterium Hymenobacter sp. strain UV11. FEMS Microbiol Lett. 2019; Aug 9. pii: fnz177. doi: 10.1093/femsle/fnz177.
Costábile, A; Koziol, U; Tort, J; Iriarte, A; Castillo, E: Expansion of CAP superfamily proteins in the genome of Mesocestoides corti: an extreme case of a general bilaterian trend. Gene Reports. 2018; 11:110-120. doi: 10.1016/j.genrep.2018.03.010.