Bases Moleculares del Desarrollo de Echinococcus granulosus
Línea fundacional de la Sección Bioquímica, liderada por el Dr. Ricardo Ehrlich. El objetivo de esta línea fue el aislamiento y caracterización de genes vinculados al desarrollo y morfogénesis del cestodo Echinococcus granulosus, agente causante de la hidatidosis.
Integrantes
Estela Castillo
Integrante
Cora Chalar
Integrante
Adriana Esteves
Integrante
Beatriz Garat
Integrante
Mónica Marín
Integrante
Claudio Martínez Debat
Integrante
Guillermo Oliver
Integrante
Mario Señorale
Integrante
Ricardo Ehrlich
Responsable: ehrlichricardo@gmail.com
Publicaciones
Ehrlich, R., Castillo, E., Chalar, C., Esteves, A., Fielitz, W., Garat, B., Marín, M., Martínez, C., Oliver, G., Pereira, Z., Picón, M. & Señorale, M..: "Echinococcus granulosus: Towards the understanding of parasitic adaptation". Basic Resarch in Helminthiases. Edited by R. Ehrlich, A. Nieto and L. Yarzabal. Ediciones Logos, Montevideo, Uruguay. pp 75-85 (1991).
Oliver, G., Vispo, M., Mailhos, A., Martínez, C., Fielitz, W., Sosa, B. & Ehrlich, R.: "Homeoboxes in Flatworms". Gene, 121: 337-342. (1992).
Ehrlich, R., Chalar, C., Dallagiovanna, B., Esteves, A., Gorfinkiel, N., Martínez, C. & Oliver, G.: “Echinococcus granulosus development: Transcription factors and differentiation markers”, in: “Molecular Biology and Immunology of the Adaptation and Differentiation of Parasites”. Ehrlich et al. eds. Ed. Logos. Montevideo, Uruguay. pp. 217-231. (1994).
Garat, B., Esperón, P., Martínez, C., Robello, C. & Ehrlich, R.: “Presence of a conserved domain of GATA-transcription factors in Echinococcus granulosus”. Journal of Helminthology, 71: 335-338 (1997).
Martínez, C., Chalar, C., González, J. and Ehrlich, R.: “The homeobox-containing gene EgHbx3 is expressed in the stalks of protoscoleces of Echinococcus granulosus”. International Journal for Parasitolgy, 27(11): 1379-1381 (1997).
Fu, Y., Martínez, C., Chalar, C., Craig, P.S., Ehrlich, R., Petavy, F. and Bosquet, G.: “A new potent antigen from Echinococcus granulosus associated with muscles and tegument”. Molecular and Biochemical Parasitology, 102(1): 43-52 (1999).
Chalar, C., Martínez, C., Agorio, A., Salinas, G., Soto, J. and Ehrlich, R.: “Molecular Cloning and Characterization of a Thioredoxin gene from Echinococcus granulosus”. Biochemical and Biophysical Research Communications, 262(1): 302-307 (1999).
Fernández, V., Chalar, C., Martínez, C., Musto, H., Zaha, A. and Fernández, C.: “Echinococcus granulosus: Molecular Cloning and Phylogenetic Analysis of a Transcriptionally Inducible Gluthathione S-Transferase”, Experimental Parasitology, 96: 190-194 (2000).
Martínez, C, Paredes, R, Stock, RP, Saralegui, A, Andreu, M, Cabezón, C, Ehrlich, R and Galanti, N: “Cellular Organization and Appearance of Differentiated Structures in Developing Stages of the Parasitic Platyhelminth Echinococcus granulosus”. Journal of Cellular Biochemistry, 94(2): 327-335 (2005).
Travençolo, BAN, Martínez, C, Beletti, ME, Sotelo Silveira, JR, Ehrlich, R and da F. Costa, L: “A distance-based approach to quantify the interplay between genetic activity and anatomy”, Journal of Anatomy, 210(2):221-31 (2007).
Chalar C. & Martínez Debat, C.: “NK homeobox-containing genes in platyhelminths”, en “Research in Helminths”. Adriana Esteves, Ed. Kerala, India: Transworld Research Network. ISBN: 978-81-7895-515-5. pp. 41-55 (2011).
Alvite G., Chalar C., Martínez Debat C. & Esteves A.: “Insights into Key Molecules of Echinococcus granulosus”. J Vet Med Res. ISSN: 2378-931X. 3(5): 1065. https://www.jscimedcentral.com/VeterinaryMedicine/veterinarymedicine-3-1065.pdf. (2016).
Chalar C., Martínez Debat C., Brauer M., Ehrlich R. and Marín M.: “eghbx2, a homeobox-gene involved in the maturation of calcified structures in Echinococcus granulosus”. Gene Reports 3:39-46. doi: 10.1016/j.genrep.2016.02.001. (2016).