Material genético de origen antártico para el desarrollo de productos biotecnológicos
Material genético de origen antártico para el desarrollo de productos biotecnológicos
La Antártida es un ambiente ideal para la identificación de moléculas con potencial innovador para el desarrollo de productos biotecnológicos. En particular, nosotros identificamos moléculas involucradas en la adaptación a las bajas temperaturas y a la radiación UV, para el desarrollo de productos con potencial uso en las industrias cosmética, médica, de los biocombustibles, papelera, etc. Entre otras moléculas, trabajamos en enzimas como las fotoliasas, peroxidasas, celulasas y proteasas, pero también como metabolitos secundarios como los pigmentos bacterianos con capacidad antiproliferante y sensibilizante al cisplatino.
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Responsable
scs@fcien.edu.uy
Publicaciones
Cagide, C.; Marizcurrena, J.J; Vallés, D.; Alvarez, B.; Castro-Sowinski, S. A bacterial cold‑active dye‑decolorizing peroxidase from an Antarctic Pseudomonas strain. Applied Microbiology and Biotechnology, 2023.107(5-6), 1707-1724. https://doi.org/10.1007/s00253-023-12405-7
Cagide, C.; García-Laviña, C. X.; Morel, M. A.; Castro-Sowinski, S. Descriptive analysis of the draft genome from the melanin-producing bacterium Sinorhizobium (Ensifer) meliloti CE52G. Environmental Sustainability. 2023, 1-12.https://doi.org/10.1007/s42398-023-00273-w
Alem, D.; Canclini, L.; Castro-Sowinski, S.; Martínez-López, W. (2022). Chemosensitizer effect of violacein on cisplatin-treated bladder cancer cells. Clinical Complementary Medicine and Pharmacology. 2022, 2(2), 100036. https://doi.org/10.1016/j.ccmp.2022.100036
Acosta, S.; Canclini, L.; Marizcurrena, J. J.; Castro-Sowinski, S.; Hernández, P. Photo-repair effect of a bacterial Antarctic CPD-photolyase on UVC-induced DNA lesions in human keratinocytes. Environmental Toxicology and Pharmacology, 2022 96, 104001.https://doi.org/10.1016/j.etap.2022.104001
Marizcurrena, J. J.; Castro-Sowinski, S.; Cerdá, M. F. Improving the performance of dye-sensitized solar cells using nanoparticles and a dye produced by an Antarctic bacterium. Environmental Sustainability, 2021, 1-11. https://doi.org/10.1007/s42398-021-00168-8
Alem, D.; Marizcurrena, J. J.; Saravia, V.; Davyt, D.; Martinez-Lopez, W.; Castro-Sowinski, S. Production and antiproliferative effect of violacein, a purple pigment produced by an Antarctic bacterial isolate. World Journal of Microbiology and Biotechnology. 2020, 36, 1-11. https://doi.org/10.1007/s11274-020-02893-4
Cagide, C.; Castro-Sowinski, S. Technological and biochemical features of lignin-degrading enzymes: A brief review. Environmental Sustainability. 2020, 3, 371-389. https://doi.org/10.1007/s42398-020-00140-y
Marizcurrena, J. J.; Acosta, S.; Canclini, L.; Hernández, P.; Vallés, D.; Lamparter, T.; Castro-Sowinski, S. A natural occurring bifunctional CPD/(6-4)-photolyase from the Antarctic bacterium Sphingomonas sp. UV9. Applied Microbiology and Biotechnology. 2020, 104: 7037-7050. https://doi.org/10.1007/s00253-020-10734-5
Marizcurrena, J. J.; Lamparter, T.; Castro-Sowinski, S. A (6-4)-photolyase from the antarctic bacterium Sphingomonas sp. UV9: recombinant production and in silico features. Extremophiles. 2020, 24(6), 887-896. https://doi.org/10.1007/s00792-020-01202-z
Torracchi C, J. E.; Morel, M. A.; Tapia-Vázquez, I.; Castro-Sowinski, S.; Batista-García, R. A.; Yarzábal R, L. A. Fighting plant pathogens with cold-active microorganisms: biopesticide development and agriculture intensification in cold climates. Applied Microbiology and Biotechnology. 2020, 104, 8243-8256.https://doi.org/10.1007/s00253-020-10812-8
Marizcurrena JJ, Martínez-López W, Ma H, Lamparter T, Castro-Sowinski S. A highly efficient and cost-effective recombinant production of a bacterial photolyase from the Antarctic isolate Hymenobacter sp. UV11. Extremophiles. (2019). doi: 10.1007/s00792-018-1059-y.
Montagni T, Enciso P, Marizcurrena JJ, Castro-Sowinski S, Fontana C, Davyt D, Cerdá MF. Dye sensitized solar cells based on Antarctic Hymenobacter sp. UV11 dyes. Environ. Sust (2018) 1:89–97 https://doi.org/10.1007/s42398-018-0007-1
Fullana, N , Braña V , Marizcurrena JJ , Morales D , Betton JM , Marin, M. , Castro-Sowinski S. Identification, recombinant production and partial biochemical characterization of an extracellular cold-active serine-metalloprotease from an Antarctic Pseudomonas isolate . AIMS Bioengineering, (2017), 4 3:386-401